Ordering Information
- : AB5864
- : 50 μL
- : Variable
Product Images
Rabbit anti-Degraded Myelin Basic Protein (Catalog Number AB5864) staining of distal segment of ligated (7 days) sciatic nerve.
Anti-Myelin Basic Protein
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R | IH | Rabbit | Serum | Polyclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P02686 # The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination
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Entrez Gene Number:
Entrez Gene Summary
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP
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Description:
Anti-Myelin Basic Protein
Alternate Names:
MBP
Specificity:
Recognizes Myelin Basic Protein in demyelinated nerve tissues. Immunohistochemistry analysis of lesioned rat spinal cord shows a high level of specificity for this antiserum.
Key Applications:
Immunohistochemistry
Application Notes:
Immunohistochemistry: 1:2,000. Immunostains myelin basic protein of abnormal appearing oligodendrocytic processes and cell bodies in demyelinating areas. The antibody recognizes only areas of myelin degeneration when tested in injured spinal cord and lesioned sciatic nerve. It also stains discrete white matter in brain of multiple system atrophy
Optimal working dilutions must be determined by the end user.
Optimal working dilutions must be determined by the end user.
Species Reactivity:
- Human
- Rat
Immunogen:
Synthetic peptide corresponding to amino acids 69-86 of the guinea pig protein.
Control:
Brain tissue
Presentation:
Rabbit Serum. Lyophilized, no preservatives. Reconstitute with 50 μL of sterile distilled water. Centrifuge to remove any residue.
Storage Conditions:
Maintain at -20 to -70°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.
Gene Symbol:
- MBP
- MGC99675
- Golli-mbp
Antibody Category:
Neuroscience
Antibody Sub-Category:
- Neuronal & Glial Markers
- Neurodegenerative Diseases
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Trade Name:
Chemicon (Millipore)
Format:
Serum
Host:
Rabbit
Concentration:
Variable
Antibody Type:
Polyclonal Antibody