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ChromaSorb 500 mL device
Description:
ChromaSorb 500 mL device
Trade Name:
ChromaSorb
Applications:
A large sized anion membrane adsorber for large volume processing for trace impurity removal in a flow through mode
Key Applications:
Large volume
Feedstock pH Range:
Typically 0.5 to 1 pH unit below the pI of the target being purified
Typical Operating Flow Rate:
500 mL device: 6500 mL/min (12.5 CV/min)
Operating Buffers:
Monovalent buffers only (e.g. Tris and acetate). ChromaSorb membrane adsorber is not recommended for use in processes that are in multivalent buffers such as phosphate and citrate as this can lead to reduced capacity.
BSA Capacity:
≥50 mg/mL on average at 0 mM NaCl
≥20 mg/mL on average at 280 mM NaCl
≥20 mg/mL on average at 280 mM NaCl
Impurity Removal:
Virus (MMV): >4 LRV
DNA: >3 LRV
Endotoxin: >3 LRV
DNA: >3 LRV
Endotoxin: >3 LRV
Nominal Membrane Volume:
500 mL device: ~503.0 mL
Permeability:
1.5 CV/min/psi
Materials of Construction:
Membrane: Ultra High Molecular Weight Polyethylene
Ligand: Primary Amine
Molded parts: High Density Polyethylene
Ligand: Primary Amine
Molded parts: High Density Polyethylene
Long Description:
The ChromaSorb 500mL device has been designed for customers looking to remove trace amounts of negatively charged impurities such as virus, HCP and endotoxin from their drug feedstocks in a flow through mode. Each device has been 100% integrity tested to ensure there is no bypass of the membrane and comes with a certificate of quality and a users guide. The Chromasorb 500 mL device is ideally suited for medium and larger batch volume processing.